USE OF POLYOLS TO OBTAIN STABLE POLYMORPHOUS FORMS OF RIFAXIMIN

摘要

Polyols stabilize polymorphous form of rifaximin, in particular theβform. When polyols having at least two hydroxy groups are added to rifaximin powder, polymorphβis stable and remains stable in time independently from the environment humidity. In this invention a method to prepare formulations constituted by pure and stable polymorphous forms able to give a pharmaceutical product is described.