| 发明名称 |
Antibody Inhibitors of GDF-8 and Uses Thereof |
| 摘要 |
The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism. |
| 申请公布号 |
US2012107928(A1) |
申请公布日期 |
2012.05.03 |
| 申请号 |
US201213346042 |
申请日期 |
2012.01.09 |
| 申请人 |
AGHAJANIAN JANE;DUNHAM WILLIAM J.;WOLFMAN NEIL M.;O'HARA DENISE;DAVIES MONIQUE V.;VELDMAN GEERTRUIDA M.;BRIDGES KRISTIE GROVE;WHITTEMORE LISA-ANNE;KHURANA TEJVIR S.;BOUXSEIN MARY L.;WYETH LLC |
发明人 |
AGHAJANIAN JANE;DUNHAM WILLIAM J.;WOLFMAN NEIL M.;O'HARA DENISE;DAVIES MONIQUE V.;VELDMAN GEERTRUIDA M.;BRIDGES KRISTIE GROVE;WHITTEMORE LISA-ANNE;KHURANA TEJVIR S.;BOUXSEIN MARY L. |
| 分类号 |
C12N15/09;C12N15/13;A61K39/395;A61P3/10;A61P11/00;A61P19/08;A61P19/10;A61P21/00;A61P21/04;A61P35/00;C07K14/475;C07K16/22;C12N5/10;C12N5/16;C12N15/02;C12P21/08 |
主分类号 |
C12N15/09 |
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