发明名称 |
COMPOSITIONS TARGETING THE SOLUBLE EXTRACELLULAR DOMAIN OF E-CADHERIN AND RELATED METHODS FOR CANCER THERAPY |
摘要 |
The present invention is based, in part, on our discovery that targeting epitopes within one or more of the EC2-EC5 subdomains of E-cadherin results in the death of epithelial -derived tumor cells but not in the death of normal, healthy epithelial cells or non-epithelial cells including endothelial cells and fibroblasts. Accordingly, the compositions of the invention include polypeptides having an amino acid sequence of one or more of the EC2-EC5 subdomains of E-cadherin and biologically active variants thereof; expression vectors and cells for expressing such polypeptides; and agents (e.g., antibodies) that target the EC2-EC5 subdomains. The methods of the invention include methods of identifying and producing polypeptides having an amino acid sequence of one or more of the EC2-EC5 subdomains of E-cadherin or a biologically active variant thereof; methods of generating agents, such as antibodies, that target these polypeptides; and methods of administering such agents or eliciting their production in vivo to treat epithelial cancers or reduce the risk of their occurrence or recurrence. |
申请公布号 |
WO2012058418(A2) |
申请公布日期 |
2012.05.03 |
申请号 |
WO2011US58076 |
申请日期 |
2011.10.27 |
申请人 |
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK;THE UNIVERSITY OF ROCHESTER;BROUXHON, SABINE;O'BANION, M. KERRY;KYRKANIDES, STEPHANOS |
发明人 |
BROUXHON, SABINE;O'BANION, M. KERRY;KYRKANIDES, STEPHANOS |
分类号 |
A61K39/395;A61K49/00;A61K49/14;A61P35/00 |
主分类号 |
A61K39/395 |
代理机构 |
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