发明名称 |
ESTROGEN RECEPTOR ALLELES THAT ARE PREDICTIVE OF INCREASED SUSCEPTIBILITY TO BONE FRACTURE |
摘要 |
In one aspect, the present invention provides methods of determining susceptibility to bone fracture in a mammalian subject, wherein the methods comprise analyzing nucleic acid molecules obtained from the mammalian subject to determine which of the P, p X, and x alleles of the estrogen receptorαgene are present, wherein the presence of a haplotype comprising the p and x alleles is indicative of an increased susceptibility to bone fracture. The present invention also provides kits for determining susceptibility to bone fracture in a mammalian subject. |
申请公布号 |
US2012107421(A1) |
申请公布日期 |
2012.05.03 |
申请号 |
US201113091403 |
申请日期 |
2011.04.21 |
申请人 |
UITTERLINDEN ANDREAS GERARDUS;MARIA VAN LEEUWEN JOHANNES PETRUS THOMAS;PIETER POLS HUIBERT ADRIAAN |
发明人 |
UITTERLINDEN ANDREAS GERARDUS;MARIA VAN LEEUWEN JOHANNES PETRUS THOMAS;PIETER POLS HUIBERT ADRIAAN |
分类号 |
A61K33/06;A61K31/59;A61P19/00;C12Q1/68 |
主分类号 |
A61K33/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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