<p>The invention relates to the fields of peptide mimetics and pharmacy. The invention provides novel cycle forming linkers and bicyclic peptide mimetics prepared therefrom. The linkers comprise an organic moiety P, leaving groups X1 and X2 at benzylic positions, and a reactive group Q capable of participating in a linking reaction. The organic moiety P contains an aromatic (hetero) cycle, an aliphatic heterocycle comprising a positively charged nitrogen atom, and a neutral nitrogen atom.</p>
申请公布号
WO2012057624(A1)
申请公布日期
2012.05.03
申请号
WO2011NL50727
申请日期
2011.10.25
申请人
PEPSCAN SYSTEMS B.V.;SMEENK, LINDE, EMMA, JOSINA;VAN MAARSEVEEN, JAN, H.;DAILLY, NICOLAS, STEPHANE;TIMMERMAN, PETER
发明人
SMEENK, LINDE, EMMA, JOSINA;VAN MAARSEVEEN, JAN, H.;DAILLY, NICOLAS, STEPHANE;TIMMERMAN, PETER