发明名称 |
SUBSTITUTED OXAZOLE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS |
摘要 |
The present invention relates to novel compounds selected from substituted oxazole derivatives of formula (I) that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant tyrosine kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. More particularly, these compounds are potent and selective c-kit, bcr-abl and Flt-3 inhibitors. |
申请公布号 |
US2012108616(A1) |
申请公布日期 |
2012.05.03 |
申请号 |
US201213343968 |
申请日期 |
2012.01.05 |
申请人 |
GRIERSON DAVID;BENJAHAD ABDELLAH;MOUSSY ALAIN;CROISY MARTINE;AB SCIENCE;INSTITUT CURIE;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) |
发明人 |
GRIERSON DAVID;BENJAHAD ABDELLAH;MOUSSY ALAIN;CROISY MARTINE |
分类号 |
A61K31/422;A61K31/4439;A61K31/513;A61P1/04;A61P11/06;A61P19/02;A61P25/00;A61P29/00;A61P35/00;A61P35/02;A61P37/00;A61P37/08;C07D263/48;C07D413/12;C07D413/14 |
主分类号 |
A61K31/422 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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