A METHOD OF OBTAINING OLMESARTAN MEDOXOMIL

摘要

A method of obtaining olmesartan medoxomil of formula I, comprising the following steps: a) detritylation of trityl olmesartan medoxomil in the presence of an organic acid and water, to give olmesartan medoxomil and trityl alcohol; b) addition of water and separation of the resulting trityl alcohol; c) addition of a water-miscible aprotic solvent; d) addition of water, to give crystalline olmesartan medoxomil; e) isolation of crystalline olmesartan medoxomil of formula I. A pharmaceutical composition comprising olmesartan medoxomil of formula I obtained by the above described method.