NOVEL PROCESS FOR PREPARING DEXIBUPROFEN READY TO COMPRESS GRANULES

摘要

A novel process of preparing dexibuprofen pharmaceutical formulation in the form of granules that can be directly compressed into tablets. The process consists of two steps: (i) preparation of base granule, and (ii) blending of base granules with compression aid to get ready to compress granules, wherein the process of preparing base granules involves use of fluid bed granulator with top spray method or slugging by roll compaction. The granules prepared by using both the methods showed improved compressibility and flowability compared to granules prepared by conventional granulation process using rapid mixer granulator. The ready to compress granules prepared process showed no signs of sticking when compressed on high speed commercial scale tablet compression machine.