HEMIOXALATE SALT OF CRYSTALLINE O-DESMETHYLVENLAFAXINE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION THEREOF

摘要

The present invention relates to hemioxalate of crystalline O-desmethylvenlafaxine which maximizes solubility and has physicochemical properties of a solid material which is pharmaceutically preferable due to its non-hygroscopicity, to a preparation method of the hemioxalate, and to a pharmaceutical composition of the hemioxalate. The hemioxalate of crystalline O-desmethylvenlafaxine according to the present invention can: increase bioavailability of drugs due to its high solubility; allow various formulations to be very easily designed without composition size limitations; and administer high doses of drugs regardless of the dose-limiting volume of an animal. Thus, the hemioxalate of crystalline O-desmethylvenlafaxine facilitates the confirmation of expressible toxicity, and is suitable for distribution of raw materials and production of medicines because of low hygroscopicity.