摘要 |
Embodiments of the invention include multi-layer coatings and methods for controlling the elution of hydrophilic active agents. In an embodiment, the invention includes a medical device including a substrate, a primer polymer layer disposed on the substrate, an expandable layer disposed on the primer polymer layer, and a hydrophilic active agent dispersed within the expandable layer. In an embodiment, the invention includes a method of forming a medical device including depositing a primer layer onto a substrate, the primer layer comprising a primer polymer. The method can further include depositing an expandable layer onto the primer layer, the expandable layer including an expandable polymer, and a hydrophilic active agent. The expandable layer can be deposited with a solvent that is effective to solvate both the expandable polymer and the primer polymer. Other embodiments are also included herein. |
申请人 |
CHAPPA, RALPH, A.;BURKSTRAND, MICHAEL, J.;BABCOCK, DAVID, E.;SURMODICS, INC. |
发明人 |
CHAPPA, RALPH, A.;BURKSTRAND, MICHAEL, J.;BABCOCK, DAVID, E. |