发明名称 |
Immunogenic bacterial vesicles with outer membrane proteins |
摘要 |
Knockout of the meningococcal homolog gives bacteria that spontaneously release vesicles that are rich in immunogenic outer membrane proteins and that can elicit cross-protective antibody responses with higher bactericidal titres than OMVs prepared by normal production processes. Thus the invention provides a bacterium having a knockout mutation of its gene. The invention also provides a bacterium, wherein the bacterium: (i) has a cell wall that includes peptidoglycan; and (ii) does not express a protein having the lytic transglycosylase activity of MltA protein. The invention also provides compositions comprising vesicles that, during culture of bacteria of the invention, are released into the culture medium. |
申请公布号 |
AU2005298332(B2) |
申请公布日期 |
2012.05.03 |
申请号 |
AU20050298332 |
申请日期 |
2005.10.28 |
申请人 |
NOVARTIS VACCINES AND DIAGNOSTICS SRL |
发明人 |
GRANDI, GUIDO;PIZZA, MARIAGRAZIA;NORAIS, NATHALIE;ADU-BOBIE, JEANNETTE;FERRARI, GERMANO |
分类号 |
A61K39/095;A61K39/108;C12N9/10;C12N15/03 |
主分类号 |
A61K39/095 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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