发明名称 |
SOLID DISPERSIONS CONTAINING AN APOPTOSIS-INDUCING AGENT |
摘要 |
<p>A pro-apoptotic solid dispersion comprises, in essentially non-crystalline form, a Bcl-2 family protein inhibitory compound of Formula I as defined herein, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises dissolving the compound, the polymeric carrier and the surfactant in a suitable solvent, and removing the solvent to provide a solid matrix comprising the polymeric carrier and the surfactant and having the compound dispersed in essentially non-crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.</p> |
申请公布号 |
CA2811805(A1) |
申请公布日期 |
2012.05.03 |
申请号 |
CA20112811805 |
申请日期 |
2011.10.27 |
申请人 |
ABBVIE INC. |
发明人 |
CATRON, NATHANIEL D.;LINDLEY, DAVID J.;MILLER, JONATHAN;SCHMITT, ERIC A.;TONG, PING |
分类号 |
A61K9/14;A61K9/48;A61K31/437;A61K47/12;A61K47/22;A61K47/26;A61K47/32;A61K47/34;A61K47/38;A61K47/44;A61P35/00 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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