METHOD FOR DETERMINING ACTIVATORS OF EXCITATORY SYNAPSE FORMATION
摘要
The invention provides methods of screening a compound that can increase spine/excitatory synapse formation and/or numbers. The compound is identified by contacting Ephexin5 with a test compound and selecting the compounds that inhibit Rho GEF activity of Ephexin5. Additionally, the invention also provides methods for increasing spine/excitatory synapse formation and/or numbers by contacting a neuron with an Ephexin5 inhibitor.
申请公布号
WO2012058201(A2)
申请公布日期
2012.05.03
申请号
WO2011US57639
申请日期
2011.10.25
申请人
PRESIDENT AND FELLOWS OF HARVARD COLLEGE;SALOGIANNIS, JOHN;GREENBERG, MICHAEL E.;MARGOLIS, SETH S.
发明人
SALOGIANNIS, JOHN;GREENBERG, MICHAEL E.;MARGOLIS, SETH S.
