METHOD FOR SCREENING, USING GABA RECEPTORS, FOR PREPARATIONS FOR PREVENTING FETAL NEURAL DISEASE CAUSED BY ALCOHOL EXPOSURE DURING PREGNANCY

摘要

The present invention relates to a method for screening for preparations for preventing fetal neural disease caused by alcohol exposure during pregnancy, comprising: a step of treating a fetus-derived specimen with ethanol to inhibit the expression of GABAB1 receptors; and a step of treating the specimen with a candidate material, and checking the increase in the expression of one or more selected from a group consisting of GABAB1 receptors, p-CREB and PKA. The present invention also relates to a method for predicting the probability of the onset of fetal neural disease caused by alcohol exposure during pregnancy, comprising measuring the decrease in the expression of GABAB1 receptors in the fetus-derived specimen exposed to alcohol. The present invention also relates to a method for preparing compositions for preventing fetal neural disease caused by alcohol exposure during pregnancy, comprising: a step of treating a fetus-derived specimen exposed to alcohol with a candidate material, and checking the increase in the expression of one or more selected from a group consisting of GABAB1 receptors, p-CREB and PKA; and a step of adding the candidate material that exhibits said increase in expression.