ISOINDOLINONE DERIVATIVES, PREPARATION?METHOD THEREOF AND A PHARMACEUTICAL COMPOSITION COMPRISING SAME

摘要

PURPOSE: An isoindolinone derivative and pharmaceutical composition containing the same are provided to enhance expression of alkaline phosphatase. CONSTITUTION: An insoindolinone derivative is denoted by chemical formula 1. A method for preparing the isoindolinone derivative comprises a step of amide-coupling phenylene diamine with a compound of chemical formula 8 to obtain an isoindolinone of chemical formula 2. In case of that one or more substituent R1-R4 in chemical formula 8 are halogen, the method further comprises a step of Suzuki-coupling boronic acid compound of chemical formula 17(RB(OH)_2) under the presence of palladium catalyst. A pharmaceutical composition for preventing or treating bone diseases contains the isoindolinone derivative of chemical formula 1 or pharmaceutically acceptable salt as an active ingredient.