发明名称 |
CIS 3,4-DIHYDROXY-2-(3-METHYLBUTANOYL)-5-(-3-METHYLBUTYL)-4-(4-METHYLPENTANOYL)CYCLOPENT-2-EN-1-ONE DERIVATIVES, SUBSTANTIALLY ENANTIOMERICALLY PURE COMPOSITIONS AND METHODS |
摘要 |
The present application provides cis 3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3- methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one derivatives and substantially enantiomerically pure compositions thereof. These derivatives include (+)-(4S,5R)- 3,4- dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one, (-)-(4R,5S)-3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4- methylpentanoyl)cyclopent-2-en-1-one, and salts and crystals thereof. The application further provides methods of using the disclosed compounds and compositions to activate PPAR?, activate GPR120, inhibit inflammation, and treat conditions responsive to PPAR? modulation, conditions responsive to GPR120 modulation, and metabolic disturbances such as diabetes. |
申请公布号 |
CA2853974(A1) |
申请公布日期 |
2012.05.03 |
申请号 |
CA20112853974 |
申请日期 |
2011.10.28 |
申请人 |
KINDEX THERAPEUTICS, LLC;CARROLL, BRIAN;DARLAND, GARY;DESAI, ANURADHA;KONDA, VEERA;DAHLBERG, CLINTON J.;URBAN, JAN |
发明人 |
CARROLL, BRIAN;DARLAND, GARY;DESAI, ANURADHA;KONDA, VEERA;DAHLBERG, CLINTON J.;URBAN, JAN |
分类号 |
C07C49/707;A61K31/122;A61P3/04;A61P3/10 |
主分类号 |
C07C49/707 |
代理机构 |
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