发明名称 |
READILY ISOLATED BISPECIFIC ANTIBODIES WITH NATIVE IMMUNOGLOBULIN FORMAT |
摘要 |
A bispecific antibody format providing ease of isolation is provided, comprising immunoglobulin heavy chain variable domains that are differentially modified in the CH3 domain, wherein the differential modifications are non-immunogenic or substantially non-immunogenic with respect to the CH3 modifications, and at least one of the modifications results in a differential affinity for the bispecific antibody for an affinity reagent such as Protein A, and the bispecific antibody is isolable from a disrupted cell, from medium, or from a mixture of antibodies based on its affinity for Protein A. |
申请公布号 |
EP2445936(A1) |
申请公布日期 |
2012.05.02 |
申请号 |
EP20100726775 |
申请日期 |
2010.06.25 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
DAVIS, SAMUEL;SMITH, ERIC;MACDONALD, DOUGLAS;OLSON, KARA, LOUISE |
分类号 |
C07K16/06;C07K16/46 |
主分类号 |
C07K16/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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