发明名称 |
Methods for treating conditions associated with MASP-2 dependent complement activation |
摘要 |
In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (C I q-dependent) pathway component of the immune system intact. In another aspect, the invention provides compositions for inhibiting the effects of lectin-dependent complement activation, comprising a therapeutically effective amount of a MASp-2 inhibitory agent and a pharmaceutically acceptable carrier. |
申请公布号 |
EP2446900(A1) |
申请公布日期 |
2012.05.02 |
申请号 |
EP20100184424 |
申请日期 |
2005.06.09 |
申请人 |
OMEROS CORPORATION;UNIVERSITY OF LEICESTER |
发明人 |
SCHWAEBLE, HANS-WILHELM;STOVER, CORDULA M.;TEDFORD, CLARK E.;PARENT, JAMES B.;FUJITA, TEIZO |
分类号 |
A61K39/395;A61K31/00;A61K38/02;A61P3/10;A61P5/00;A61P9/00;A61P21/00;A61P37/00;C07K16/40 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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