发明名称 |
Method of regulating mammalian target-of-rapamycin activity by interaction between phospholipase D and Rheb |
摘要 |
The present invention relates to method of regulating mammalian target-of-rapamycin (mTOR) based on a novel finding of a regulating mechanism of mTOR by a phospholipase D (PLD), and Ras homolog enriched in brain (Rheb). Further, the present invention also relates to a method of screening inhibitors of mTOR, and a method and a composition for treating mTOR-related metabolic diseases by inhibiting mTOR. |
申请公布号 |
US8168177(B2) |
申请公布日期 |
2012.05.01 |
申请号 |
US20070374239 |
申请日期 |
2007.08.03 |
申请人 |
RYU SUNG-HO;SUH PANN-GHILL;HA SANG-HOON;LEE MI-NAM;LEE HYUN-JU;KIM IL-SHIN;KIM DO-HYUNG;LEE TAE-HOON;POSTECH ACADEMY-INDUSTRY FOUNDATION |
发明人 |
RYU SUNG-HO;SUH PANN-GHILL;HA SANG-HOON;LEE MI-NAM;LEE HYUN-JU;KIM IL-SHIN;KIM DO-HYUNG;LEE TAE-HOON |
分类号 |
A61K38/46;C12N9/14 |
主分类号 |
A61K38/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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