发明名称 |
[1,4]-BENZODIAZEPINES AS VASOPRESSIN V2 RECEPTOR ANTAGONISTS |
摘要 |
<p>The invention relates to a novel class of [1,4]-benzodiazepine derivatives, processes for their preparation, intermediates usable in these processes, and pharmaceutical compositions containing the compounds. Other aspects of the invention are directed to the use of said [1,4]-benzodiazepine derivatives in therapy based on the capability of said compounds to interfere with the binding of the peptide hormone, vasopressin, to its receptors. In particular as vasopressin V2 receptor antagonists and therefore useful for treating involving increased vascular resistance, cardiac insufficiency, and water retention.</p> |
申请公布号 |
SG179056(A1) |
申请公布日期 |
2012.04.27 |
申请号 |
SG20120016481 |
申请日期 |
2010.09.23 |
申请人 |
SHIRE-MOVETIS N.V. |
发明人 |
MEULEMANS, ANN;LAVRIJSEN, KAREL;COOLS, MARINA;KELLER, ERIK;MEZINE, IGOR, ALEXNADROVICH;THIELEMANS, LEEN;VAN GEFFEN, MAARTEN |
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