发明名称 |
TARGETS FOR TUMOR GROWTH INHIBITION |
摘要 |
<p>The present invention relates to methods for treating cancers by manipulating atarget gene expression by up-regulation silencing and/or down-regulation of the gene, such asEGFR-RP.TRAI.TNFSF13 and ZFP236 respectively. The methods are useful in treatingcancers and/or inhibiting tumor growth by enhancing expression of a gene that is validated as atarget such as ict1030 for protein peptide drug and gene therapy modalities; or by RNAinterference to silence and/or down-regulate targets such as ICT1024, ICT1025 and ICT1031 andICB 1003 that are validated for antibody, small molecule and other inhibitor drug modalities.No Suitable Figure101</p> |
申请公布号 |
SG179290(A1) |
申请公布日期 |
2012.04.27 |
申请号 |
SG20070164148 |
申请日期 |
2004.04.01 |
申请人 |
INTRADIGM CORPORATION |
发明人 |
LU, PATRICK, Y.;XIE, FRANK, Y.;WOODLE, MARTIN, C.;LIU, YIJIA;TANG, QUINN Q.;XU, JUN |
分类号 |
A61K;A61K48/00;C07H21/04;C07K14/47;C07K14/475;C07K14/71;C07K16/30;C12N15/11;C12N15/113;C12Q1/68;G01N33/574 |
主分类号 |
A61K |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|