| 摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention relates to medicine, namely to chemical-pharmaceutical industry and can be applied for industrial manufacturing injection preparation of alpha-fetoprotein (AFP). AFP is obtained from placental and(or) abortion human blood, by separation of ballast proteins from blood by centrifugation, filtration, carrying out chromatographic purifications, stabilisation by dextran, characterised by the fact that before centrifugation auxiliary substances - sodium chloride, triton X-100, chloroform and aprotinin are added. ^ EFFECT: reduction of number of technological operations with simultaneous reduction of production process duration and increase of output of product obtained during one technological cycle with preservation of purity of obtained alpha fetoprotein and its effectiveness as medication, fixation of optimal modes of cooling, freezing, sublimation and desorption of AFP preparation, reduction of energy consumption, improvement of stability of obtained preparation in storage. ^ 7 cl, 1 ex |
