摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention refers to medicine and pharmaceutical industry, and concerns a method for preparing a dosage form of a hypolipidemic, hypoglycemic agent of thioctic (-lipoic) acid. A mixture of thioctic acid, microcrystalline cellulose and lactose is wetted with hydroxypropyl methyl cellulose in the mixture of water and ethanol; the wetted mass is mixed, dried, granulated; the granulate is added with magnesium alumomethasilicate, primojel, magnesium and/or calcium stearate, sodium stearylfumarate, aerosil and/or talc; the tablets are pressed and coated with the film Opadry II. As a result, there are produced the coated tablets containing thioctic acid 300 mg and 600 mg as the active substance. ^ EFFECT: prepared drug preparation provides effective daily dosage - 600 mg/day for 1 - 2 intakes; the preparation is storage stable. ^ 2 cl, 4 ex |