FUSION CONSTRUCTS AND USE OF SAME TO PRODUCE ANTIBODIES WITH INCREASED FC RECEPTOR BINDING AFFINITY AND EFFECTOR FUNCTION

摘要

FUSION CONSTRUCTS AND USE OF SAME TO PRODUCE ANTIBODIES WITHThe present invention relates to the field of glycosylation engineering of proteins. Moreparticularly, the present invention relates to nucleic acid molecules, including fusion constructs,having catalytic activity and the use of same in glycosylation engineering of host cells to generatepolypeptides with improved therapeutic properties, including antibodies with increased Fcreceptor binding and increased effector function.Fig. 24