| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide an in vitro biomechanical model used to applied hemodynamic (i.e., blood flow) patterns modeled after the human circulation to human/animal cells in culture. <P>SOLUTION: The in vitro biomechanical model is used to applied hemodynamic (i.e., blood flow) patterns modeled after the human circulation to human/animal cells in culture; two to three or more different cell types permitted to be physically separated within the culture dish environment, and the inner cellular surface exposed to the simulated hemodynamic flow patterns; and custom in-flow and out-flow tubing to supply media, drugs, etc., separately and independently to both the inner and outer chambers of a co-culture model. The physical separation of adherent cells by an artificial transwell membrane and the bottom of a Petri dish permits each cell layer, or surface to be separately isolated for an array of biological analyses (i.e., protein, gene, etc.). <P>COPYRIGHT: (C)2012,JPO&INPIT |
