METHODS AND DEVICE TO REDUCE SLOSH ENERGY ABSORPTION EFFECTS BY REDUCING BLOOD FLOW FROM THE CRANIUM

摘要

Venous compression in the neck reduced the extent of axonal injury in a standardized mild TBI model in rodents. The mechanism restricted brain venous drainage and increased the central nervous system blood volume and pressure, thus shifting intracranial physiology to the steep part of the volume-compliance curve. The lack of compliance inside the confines of the skull and spinal canal prevented slosh energy absorption and the resultant axonal injury by causing them to approach a more elastic collision when the skull was struck during the weight drop method. A first embodiment can be a device comprising a means to reduce SLOSH energy absorption in a fluid containing organism by reducing the flow of one or more outflow vessels of the cranium by compressing said vessels.