发明名称 |
DISCOVERY OF REGULATORY T CELLS PROGRAMMED TO SUPPRESS AN IMMUNE RESPONSE |
摘要 |
A method to treat an autoimmune disease is provided. The method involves administration of interleukin-15 receptor (IL-15R) agonists in an amount effective to ameliorate a symptom of the autoimmune disease. The invention also involves a method to treat an autoimmune disease by ex- vivo expansion of CD44+CD122+Kir+ CD8+ Treg cells and administration of the CD44+CD122+Kir+ CD8+ Treg cells. Compositions comprising CD44+CD122+Kir+ CD8+ Treg cells are also provided. Methods for stimulating an immune response to an antigen are also provided. |
申请公布号 |
CA2815000(A1) |
申请公布日期 |
2012.04.26 |
申请号 |
CA20112815000 |
申请日期 |
2011.10.18 |
申请人 |
DANA-FARBER CANCER INSTITUTE, INC. |
发明人 |
CANTOR, HARVEY;KIM, HYE-JUNG;LU, LINRONG |
分类号 |
H04N5/93;A01H5/00;A01H5/08;A01H5/12;A23L19/00;A23L19/12;A61K38/20;C12N5/10;C12N15/63 |
主分类号 |
H04N5/93 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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