发明名称 |
SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS BETA-SECRETASE INHIBITORS |
摘要 |
The present invention is directed to substituted imidazo[1,2-a]pyridine derivatives, pharmaceutically acceptable salts thereof, and tautomers of such compounds or salts, that inhibit &bgr;-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which BACE is involved. |
申请公布号 |
US2012101093(A1) |
申请公布日期 |
2012.04.26 |
申请号 |
US201113214762 |
申请日期 |
2011.08.22 |
申请人 |
MJALLI ADNAN M. M.;HARI ANITHA;GADDAM BAPU;GOHIMUKKULA DEVI REDDY;POLISETTI DHARMA RAO;EL ABDELLAOUI HASSAN;RAO MOHAN;ANDREWS ROBERT CARL;XIE RONGYUAN;REN TAN;HIGH POINT PHARMACEUTICALS, LLC |
发明人 |
MJALLI ADNAN M. M.;HARI ANITHA;GADDAM BAPU;GOHIMUKKULA DEVI REDDY;POLISETTI DHARMA RAO;EL ABDELLAOUI HASSAN;RAO MOHAN;ANDREWS ROBERT CARL;XIE RONGYUAN;REN TAN |
分类号 |
A61K31/437;A61K31/444;A61K31/4545;A61K31/496;A61K31/506;A61K31/5377;A61P25/28;C07D471/04 |
主分类号 |
A61K31/437 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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