发明名称 |
METHODS FOR PROLIFERATION OF ANTIGEN-SPECIFIC T CELLS |
摘要 |
Methods for expansion of antigen-specific T cells are provided. Said methods include following steps: generating antigen-specific T cells by stimulation of T cells with antigen A; introducing genes encoding immune recognition molecule specific to major histocompatibility complex (MHC) molecule bound with a peptide derived from antigen B into the antigen A specific T cell to produce bi-specific T cells recognizing both target cells expressing antigen A peptide associated MHC and target cells expressing antigen B peptide associated MHC; stimulating the bi-specific T cells by antigen A for expansion of the bi-specific T cells in vitro or in vivo. Methods of the present invention can be applied to expand various of T cells with specific to cancer cells with tumor antigen peptide loaded MHC molecules for adoptive therapy against unmet medical need such as tumors etc. |
申请公布号 |
US2012100180(A1) |
申请公布日期 |
2012.04.26 |
申请号 |
US200913254039 |
申请日期 |
2009.04.03 |
申请人 |
GAO BIN;DING JIE;INSTITUTE OF MICROBIOLOGY,CHINESE ACADEMY OF SCIENCES |
发明人 |
GAO BIN;DING JIE |
分类号 |
A61K39/12;A61K39/00;A61K39/02;A61P31/04;A61P31/12;A61P37/04;C12N15/85;C12N15/86 |
主分类号 |
A61K39/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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