Guanadinylated aminoglycoside-lipid conjugates are prepared. Such conjugates may comprise an aminoglycoside such as an aminoglyucoside antibiotic like neomycin or kanamycin, at least one guanidino group attached to a primary or secondary carbon atom of the aminoglyucoside group and at least one lipid group attached through a bond or a linker to a branched carbon atom of the aminoglycoside. These conjugates exhibit improve antibacterial activity and may be used in conjunction with another antibiotic.
申请公布号
WO2012004684(A3)
申请公布日期
2012.04.26
申请号
WO2011IB02534
申请日期
2011.03.04
申请人
UNIVERSITY OF MANITOBA;SCHWEIZER, FRANK;SMRITILEKHA, BERA;ZHANEL, GEORGE