| 摘要 |
The present invention relates to a multistep method of preparing a highly biocompatible, bioactive and readily degradable hydroxyapatite (H?) from bovine cortical bones. The naturally prepared HA has a great potential to be used as a viable and economical biomaterial for traumatology, orthopedics, dentistry, mandibular, maxillofacial and craniofacial surgery and can serve as a scaffold for cell culture and carrier for drug delivery systems. The said method comprises mechanical and ionic detergent cleansing of bones followed by alternating hydrothermal and alkali treatments applied in repeated manner and then firing at low temperature not exceeding 650 °C under strong oxidizing atmosphere. The end product is provided in particulate form having a wide size range, namely 2000- 1000, 1000-600, 600-250 and less than 250 micron to meet the requirements of various biomedical applications. The developed process is characterized by high productivity that provides the said material in an economic level to meet the needs of the Egyptian patients through a simple and low cost local technology and additionally saves foreign currency paid for importation.
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