发明名称 |
Compounds For Enzyme Inhibition |
摘要 |
Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsin-like activity of the 20S proteasome may be selectively inhibited with the inventive compounds. The peptide-based compounds include an epoxide or aziridine, and functionalization at the N-terminus. Among other therapeutic utilities, the peptide-based compounds are expected to display anti-inflammatory properties and inhibition of cell proliferation.
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申请公布号 |
US2012101025(A1) |
申请公布日期 |
2012.04.26 |
申请号 |
US201113341022 |
申请日期 |
2011.12.30 |
申请人 |
SMYTH MARK S.;LAIDIG GUY J.;BORCHARDT RONALD T.;BUNIN BARRY A.;CREWS CRAIG M.;MUSSER JOHN H.;SHENK KEVIN D.;RADEL PEGGY A.;ONYX THERAPEUTICS, INC. |
发明人 |
SMYTH MARK S.;LAIDIG GUY J.;BORCHARDT RONALD T.;BUNIN BARRY A.;CREWS CRAIG M.;MUSSER JOHN H.;SHENK KEVIN D.;RADEL PEGGY A. |
分类号 |
A61K38/06;A61P1/00;A61P1/16;A61P1/18;A61P9/04;A61P9/10;A61P11/00;A61P11/06;A61P11/08;A61P13/12;A61P17/00;A61P17/06;A61P19/02;A61P21/00;A61P25/00;A61P25/02;A61P25/16;A61P25/28;A61P27/02;A61P29/00;A61P31/00;A61P31/04;A61P31/12;A61P31/18;A61P33/00;A61P35/00;A61P37/00;A61P37/06;A61P37/08;C07K5/06;C07K5/08;C07K5/087 |
主分类号 |
A61K38/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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