发明名称 |
TARGETED LIPOSOMES COMPRISING N-CONTAINING BISPHOSPHONATES AND USES THEREOF |
摘要 |
The present is based on the finding that folate targeted liposomal alendronate (FT-AL-L) was significantly more potent against two tested cancer cell lines than the free alendronate (AL) or the non-targeted liposomal alendronate (AL-L), as observed by the increased cytotoxicity of the folate targeted liposomal alendronate. Thus, the present disclosure provides targeted liposomes comprising a membrane and an intraliposomal core, the membrane comprising at least one liposome forming lipid and a targeting moiety, such as folate, exposed at the membrane's outer surface; and the intraliposomal core comprising encapsulated therein least one N-containing bisphosphonate. Also provided by the present disclosure are methods of use of the targeted liposomes such as for the treatment of a disease or disorder. |
申请公布号 |
US2012100206(A1) |
申请公布日期 |
2012.04.26 |
申请号 |
US201013377629 |
申请日期 |
2010.06.10 |
申请人 |
SHMEEDA HILARY;GABIZON ALBERTO A.;YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREWUNIVERSITY OF JERUSALEM, LTD. |
发明人 |
SHMEEDA HILARY;GABIZON ALBERTO A. |
分类号 |
A61K9/127;A61K31/663;A61K31/675;A61P19/10 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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