| 摘要 |
The present invention provides: a uni-lamellar liposome having an improved water-soluble medicinal agent encapsulation rate; and a process for producing the uni-lamellar liposome. This uni-lamellar liposome is characterized in that an inner aqueous phase is composed of an aqueous solvent (W1) having, dissolved therein, a water-soluble lipid component (Fw) composed of a lipid having a ClogP value smaller than 11. This process for producing the uni-lamellar liposome is characterized by comprising: (1) a primary emulsification step of dissolving a water-soluble lipid component (Fw) in an aqueous solvent (W1), dissolving a mixed lipid component (F1) that does not contain the water-soluble lipid (Fw) in an organic solvent (O), and mixing/emulsifying these solutions with each other, thereby preparing W1/O emulsion; (2) a secondary emulsification step of mixing/emulsifying the W1/O emulsion produced in step (1) with an aqueous solvent (W2), thereby preparing a W1/O/W2 emulsion; and (3) a solvent removal step of removing the organic solvent from the W1/O/W2 emulsion produced in step (2), thereby preparing an aqueous liposome suspension. |
