发明名称 |
RAPID HIGH RESOLUTION, HIGH THROUGHPUT RNA STRUCTURE, RNA-MACROMOLECULAR INTERACTION, AND RNA-SMALL MOLECULE INTERACTION MAPPING |
摘要 |
Compositions and methods are provided for a rapid, high-resolution, high-throughput method for determining the intramolecular interactions between the nucleotides present in an polynucleotide, such that single-stranded nucleotides, and nucleotides in a double-stranded configuration are distinguished and identified. Tertiary contacts and solvent accessible regions may also be determined, where such contacts and regions may result from a single stranded configuration, intermolecular interactions with other macromolecules including, without limitation, DNA, protein, RNA, etc.; intermolecular interactions with small molecules which may include drug candidates; or a combination of macromolecules and small molecules. |
申请公布号 |
WO2012054809(A2) |
申请公布日期 |
2012.04.26 |
申请号 |
WO2011US57232 |
申请日期 |
2011.10.21 |
申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY;GLENN, JEFFREY S.;PANG, PHILLIP S.;PATEL, SHRIPA |
发明人 |
GLENN, JEFFREY S.;PANG, PHILLIP S.;PATEL, SHRIPA |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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