发明名称 |
HOMOZYGOUS AND HETEROZYGOUS IDH1 GENE-DEFECTIVE HUMAN ASTROCYTOMA CELL LINES |
摘要 |
We provide IDH1 gene-defective cell lines (e.g., IDH1R132H heterozygous and IDH1R132H homozygous) derived from dissociated human astrocytoma samples. The cells can be used alone or in combination with each other or other cell types as a tool for determining the impact of IDH1R132H on cellular biology, tumorigenesis, and metabolic profiles. The cell lines may be used to test and identify therapeutic targets and to screen for molecular therapeutic agents. |
申请公布号 |
WO2012054915(A2) |
申请公布日期 |
2012.04.26 |
申请号 |
WO2011US57466 |
申请日期 |
2011.10.24 |
申请人 |
DUKE UNIVERSITY;YAN, HAI;BIGNER, DARRELL;GENGLIN, JIN |
发明人 |
YAN, HAI;BIGNER, DARRELL;GENGLIN, JIN |
分类号 |
C12N5/071;C12N5/10;C12Q1/02 |
主分类号 |
C12N5/071 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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