A CONJUGATE BETWEEN A THIOPHILIC SOLID PHASE AND AN OLIGONUCLEOTIDE COMPRISING A THIOOXONUCLEOTIDE

摘要

The present invention relates to an oligonucleotide-solid phase conjugate, wherein the solid phase is thiophilic, wherein the oligonucleotide comprises at least one thiooxonucleobase according to Formula I, wherein X is CH or N, wherein R1 is H or NH2, wherein --- indicates a covalent bond, and wherein said oligonucleotide is bound to said solid phase via the sulfur atom of said thiooxonucleotide. It also discloses a method for producing such conjugate as well as various uses for such oligonucleotide metal conjugate.