Multivesicular liposomes are prepared at commercial scales by combining a first w/o emulsion with a second aqueous solution to form a w/o/w emulsion using a static mixer. Solvent is removed from the resulting emulsion to form multivesicular liposome-containing compositions. Further optional process steps include primary filtration and secondary cross-flow filtration. The products produced according to the processes of the invention can be produced through a series of aseptic steps.
申请公布号
EP1030652(B1)
申请公布日期
2012.04.25
申请号
EP19980957937
申请日期
1998.11.13
申请人
PACIRA PHARMACEUTICALS, INC.
发明人
HARTOUNIAN, HARTOUN;MEISSNER, DAGMAR;PEPPER, CLINT, B.