发明名称 |
TRIPEPTIDE BORONIC ACID OR BORONIC ESTER, PREPARATIVE METHOD AND USE THEREOF |
摘要 |
The present invention discloses proteasome inhibitors of tripeptide boronic acids or boronic esters represented by Formula (I), preparative method and use thereof. The proteasome inhibitors are therapeutical agents for treating malignant tumor, various nervous system degenerative diseases, muscle cachexia or diabetes, wherein the malignant tumor is leukemia, gastric cancer, hepatocarcinoma or nasopharyngeal carcinoma. |
申请公布号 |
EP2444411(A1) |
申请公布日期 |
2012.04.25 |
申请号 |
EP20100788772 |
申请日期 |
2010.05.17 |
申请人 |
PEKING UNIVERSITY |
发明人 |
LI, RUNTAO;CUI, JINGRONG;ZHU, YONGQIANG;YAO, SHUYANG;GE, ZEMEI;CHENG, TIEMING |
分类号 |
C07K5/08;A61K31/69;A61K38/06;A61P3/10;A61P25/00;A61P25/28;A61P35/00;A61P35/02;A61P35/04;A61P43/00;C07F5/02;C07F5/04 |
主分类号 |
C07K5/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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