A NOVEL METHOD OF MAKING ENDOXIFEN

摘要

PURPOSE: A manufacturing method of endoxifen is provided to lower manufacturing cost and obtain high purity edoxifen with high yield. CONSTITUTION: A manufacturing method of Z-form edoxifen which is represented by chemical formula 1 comprises the following steps: a first step of protecting one -OH in 4,4- hydroxybenzophenone using a protective group; a 2nd step of coupling the outcome of the first step with propiophenone; a 3rd step of O-alkylating hydroxyl group in the outcome of the 2nd step; a 4th step of unprotecting the protective group which is attached to the hydroxyl group; a 5th step of unprotecting a protective group of alkyl moiety which is combined by the O-alkylation; and a 6th step of fractional crystallizing the outcome of the 5th step using an organic solvent.