发明名称 NOVEL SAPONIN COMPOUNDS,METHODS OF PREPARATION THEREOF,USE THEREOF AND PHARMACEUTICAL COMPOSITIONS
摘要 This invention relates to novel saponin compounds of formula II wherein MBz denotes p-methoxybenzoyl, and R is selected from the group comprising C6-10 aryl, C6-10 aryl-C1-4 alkyl-, C1-18 alkanoyl, C3-18 alkenyl, C6-10 aryl-C(O)-, C6-10 aryl-C1-4 alkyl-C(O)-, wherein each of the groups can optionally be substituted. These compounds possess a selective cytostatic activity, useful, e.g., in the treatment of proliferative diseases. The invention further relates to methods of preparation of the novel compounds and to a pharmaceutical composition containing these compounds.
申请公布号 ZA201105443(B) 申请公布日期 2012.04.25
申请号 ZA20110005443 申请日期 2011.07.22
申请人 UNIWERSYTET W BIALYMSTOKU;UNIVERZITA PALACKEHO V OLOMOUCI;BIOAPEX, S.R.O 发明人 MORZYCKI JACEK WITOLD;OKLESTKOVA JANA;STRNAD MIROSLAV;WOJTKIELEWICZ AGNIESZKA;HOFFMANNOVA LUCIE
分类号 A61K;A61P;C07J 主分类号 A61K
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