| 摘要 |
The present invention relates to the use of fumaric acid amides of the general for-mula (I) ( see formula I) wherein R1 represents OR3 or a D- or L-amino acid radical -NH-CHR4-COOH bonded via an amide bond, wherein R3 is hydrogen, a straight-chained or branched, optionally substituted C1-24 alkyl radical, a phenyl radical or C6- 10 aralkyl radical and R4 is a side chain of a natural or synthetic amino acid and R2 represents a D- or L-amino acid radical -NH-CHR5-COOH bonded via an amide bond or a peptide radical comprising 2 to 100 amino acids bonded via an amide bond, wherein R5 is a side chain of a natural or synthetic amino acid, for preparing a drug (1) for the therapy of an autoimmune disease; (2) for use in transplantation medicine; (3) for the therapy of mitochondrial diseases (4) for the therapy of NF-kappaB mediated diseases
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