发明名称 |
Nucleic acids encoding a chimeric polypeptide comprising IL-7 and HGF-beta chain and methods of use |
摘要 |
The present invention relates to a single-chain or chimeric polypeptide comprising a cytokine and a growth factor linked by at least one amino acid residue, and wherein the chimeric polypeptide enhances the proliferation and/or differentiation of hematopoietic precursor cells. In particular the invention relates to, a chimeric polypeptide comprising the beta-chain of hepatocyte growth factor, and IL-7 linked by at least one amino acid, and wherein the chimeric polypeptide demonstrates pre-pro-B proliferation and growth stimulating activity. |
申请公布号 |
US8163520(B2) |
申请公布日期 |
2012.04.24 |
申请号 |
US20090537622 |
申请日期 |
2009.08.07 |
申请人 |
GOLDSCHNEIDER IRVING;LAI LAIJUN;UNIVERSITY OF CONNECTICUT |
发明人 |
GOLDSCHNEIDER IRVING;LAI LAIJUN |
分类号 |
C12N5/10;A61K38/00;C07K14/475;C07K14/54;C12N15/12;C12N15/19;C12N15/24;C12N15/63;C12P21/04 |
主分类号 |
C12N5/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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