TOLEROGENIC PEPTIDES FROM MYELIN BASIC PROTEIN

摘要

There is provided a peptide which is capable of binding to an MHC class I or II molecule without further processing (i.e. an apitope) which comprises a portion of the region (131-158) of myelin basic protein, in particular there is provided an apitope which is selected from the following myelin basic protein peptides: (134-148, 135-149, 136-150, 137-151, 138-152, 139-153, 140-154). There is also provided the use of such a peptide in a pharmaceutical composition and a method to treat and/or prevent a disease using such a peptide.