发明名称 |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors |
摘要 |
The present invention provides diagnostic methods for predicting the effectiveness of treatment of a cancer patient with an IGF-1R kinase inhibitor. Methods are provided for predicting the sensitivity of tumor cell growth to inhibition by an IGF-1R kinase inhibitor, comprising assessing whether the tumor cell expresses certain sensitivity or resistance biomarkers, or genomic classifiers. Improved methods for treating cancer patients with IGF-1R kinase inhibitors that incorporate this methodology are also provided. |
申请公布号 |
US8163509(B2) |
申请公布日期 |
2012.04.24 |
申请号 |
US20090582013 |
申请日期 |
2009.10.20 |
申请人 |
ECKHARDT SUE GAIL;PITTS TODD MICHAEL;TAN AIK CHOON;THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODYCORPORATE |
发明人 |
ECKHARDT SUE GAIL;PITTS TODD MICHAEL;TAN AIK CHOON |
分类号 |
G01N33/574;C12Q1/68;G01N33/53 |
主分类号 |
G01N33/574 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|