Method for using DNA repair capacity as a biomarker of breast cancer risk in women

摘要

The present invention presents a method for using DNA repair capacity (DRC) as a blood biomarker to calculate the risk of a female subject developing breast cancer obtained from a blood sample by using a luciferase reporter gene method that permits calculating a percent DRC for the subject. A subject with a percent DRC below 3.1% is considered as being at risk for breast cancer and a subject with a percent DRC above 3.1% as being at low risk for breast cancer. This method comprises a further estimation of an adjusted risk of the subject to develop breast cancer using a logistic regression equation in which the DRC value is included as one of the variables.