发明名称 4-METHYLANILIDE-N-n-PROPYLPYRROLIDINE-2-CARBOXYLIC ACID BORATE, HAVING ANTHELMINTHIC ACTIVITY
摘要 FIELD: chemistry. ^ SUBSTANCE: invention relates to a novel compound 4-methylanilide-N-n-propylpyrrolidine-2-carboxylic acid borate of formula: ^ , having anthelminthic activity. The compound is obtained through bromination of 5-chlorovaleric acid with subsequent conversion thereof into an acid chloride using thionyl chloride, further amination with 4-methylaniline and then ring closure with n-propylamine in 4-methylanilide-N-n-propylpyrrolidine-2-carboxylic acid and reaction of the latter with boric acid. ^ EFFECT: high activity of the compound. ^ 1 tbl
申请公布号 RU2448089(C1) 申请公布日期 2012.04.20
申请号 RU20100147214 申请日期 2010.11.18
申请人 GOSUDARSTVENNOE OBRAZOVATEL'NOE UCHREZHDENIE VYSSHEGO PROFESSIONAL'NOGO OBRAZOVANIJA "PERMSKAJA GOSUDARSTVENNAJA FARMATSEVTICHESKAJA AKADEMIJA FEDERAL'NOGO AGENTSTVA PO ZDRAVOOKHRANENIJU I SOTSIAL'NOMU RAZVITIJU" (GOU VPO PGFA ROSZDRAVA) 发明人 KALININ DMITRIJ VADIMOVICH;PANTSURKIN VLADIMIR IVANOVICH;SYROPJATOV BORIS JAKOVLEVICH;VAKHRIN MIKHAIL IVANOVICH;MILOSERDOVA ANNA VLADIMIROVNA;KOVALEVA MARINA JUR'EVNA
分类号 A61K31/10;C07D207/10 主分类号 A61K31/10
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