| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to a novel derivative of (3-amino-1,2,3,4-tetrahydro-9-H-carbazol-9-yl)acetic acid of formula where: R1, R2, R3 and R4 independently denote H, C1-5-alkyl, C1-5-alkoxy, C2-7-alkenyl, halogen, NO2, CN, halo-C1-6-alkoxy, halo-C1-6-alkyl, C1-6-alkylsulphonyl, formyl; R5 denotes H, C2-7-alkenyl, C1-6-alkyl, C3-10-cycloalkyl-C1-4-alkyl, C1-3-alkoxy-C1-4-alkyl, aryl-C1-4-alkyl, aryloxy-C1-4-alkyl, where aryl denotes an unsubstituted mono- or disubstituted group, independently selected from C1-2-alkylenedioxy, C1-4-alkoxy, C1-4-alkyl, halogen, CF3, CF3O; R6 denotes aryl-C1-3-alkoxy-C1-3-alkoxycarbonyl, aryl-C1-3-alkoxycarbonyl, aryl-C1-3-alkylaminocarbonyl, aryl-C1-6-alkylcarbonyl, aryl-C1-3-alkoxy-C1-3-alkylcarbonyl, arylcarbonyl-C1-4-alkylcarbonyl, aryloxy-C1-3-alkylcarbonyl, C3-10-cycloalkyl-C1-3-alkylcarbonyl, diaryl-C1-3-alkylcarbonyl, heteroaryl-C1-3-alkylcarbonyl, aryl-C3-6-cycloalkylcarbonyl, R7 -C1-4-alkylcarbonyl, where the bridge C1-4-alkyl group can further be monosubstituted with aryl, and R7 denotes arylaminocarbonyl, heteroarylaminocarbonyl, C1-6-alkylaminocarbonyl, aryl-C1-3-alkylaminocarbonyl, where aryl denotes phenyl, naphthyl, which are unsubstituted, mono- or disubstituted with a group independently selected from C1-2-alkylenedioxy group, C1-6-alkoxy group, C1-6-alkyl, C1-6-alkylsulphonyl, halogen, hydroxy group, halo-C1-6-alkyl, halo-C1-6-alkoxy group, C1-6-alkylthio group and C1-4-alkoxycarbonylamino group, and heteroaryl denotes a 5-10-member aromatic ring system, where 1-3 of said atoms are heteroatoms selected N, O, S, or pharmaceutically acceptable salts thereof. ^ EFFECT: compounds have hCRTH-2 antagonist activity, which allows for their use in a pharmaceutical composition. ^ 14 cl, 12 tbl, 251 ex |
