CLATHRATE COMPLEXES OF BETA-CYCLODEXTRIN WITH 1-{[6-BROMO-1-METHYL-5-METHOXY-2-PHENYLTHIOMETHYL-1-H-INDOL-3-YL]CARBONYL}-4-BENZYLPIPERAZINE, HAVING ANTIVIRAL ACTIVITY, SYNTHESIS AND USE THEREOF

摘要

FIELD: chemistry. ^ SUBSTANCE: invention relates to a novel clathrate complex of -cyclodextrin with 1-{[6-bromo-1-methyl-5-methoxy-2-phehylthiomethyl-1-H-indol-3-yl]carbonyl}-4-benzylpiperazine of formula : with molar ratio 1-{[6-bromo-1-methyl-5-methoxy-2-phehylthiomethyl-1-H-indol-3-yl]carbonyl}-4-benzylpiperazine: -cyclodextrin from 1:1 to 1:10, synthesis method and use thereof as an antiviral agent for treating influenza. The disclosed method involves mixing solutions of -cyclodextrin and 1-{[6-bromo-1-methyl-5-methoxy-2-phehylthiomethyl-1-H-indol-3-yl]carbonyl}-4-benzylpiperazine in molar ratio from 1:1 to 1:10 while stirring and heating to temperature not higher than 70C and then maintaining said conditions until a homogeneous solution is obtained and extraction of the obtained complex. ^ EFFECT: clathrate complex is a novel effective anti-influenza virus agent which is obtained using a novel efficient method. ^ 13 cl, 2 ex, 3 tbl, 11 dwg