PROCESS FOR PREPARING 2-(2-HYDROXYPHENYL)-BENZ[1,3]OXAZIN-4-ONE AND ITS USE FOR PREPARING DEFERASIROX

摘要

Disclosed is a process for the synthesis of 2-(2-hydroxyphenyl)-benz[1,3]oxazin-4-one, the process comprising reacting salicylic acid with p-toluenesulfonyl chloride in the presence of a base and an organic solvent, and then combining the obtained tosylated compound with salicylamide. The use of2-(2-hydroxyphenyl)-benz[13]oxazin-4-one in the preparation of Deferasirox is also disclosed.